Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

被引：0

作者：

Sarah M Barry

Johan A Kers

Evan G Johnson

Lijiang Song

Philip R Aston

Bhumit Patel

Stuart B Krasnoff

Brian R Crane

Donna M Gibson

Rosemary Loria

Gregory L Challis

机构：

[1] University of Warwick,Department of Chemistry

[2] Cornell University,Department of Plant Pathology and Plant

[3] Cornell University,Microbe Biology

[4] Agricultural Research Service,Department of Chemistry and Chemical Biology

[5] Robert W. Holley Center for Agriculture and Health,United States Department of Agriculture

[6] Present addresses: Department of Chemistry,undefined

[7] School of Biomedical Sciences,undefined

[8] King's College London,undefined

[9] London,undefined

[10] UK (S.M.B.); Industrial Products Division,undefined

[11] Intrexon Corporation,undefined

[12] San Carlos,undefined

[13] California,undefined

[14] USA (J.A.K.); Citrus Research and Education Center,undefined

[15] University of Florida,undefined

[16] Lake Alfred,undefined

[17] Florida,undefined

[18] USA (E.G.J.); Fraunhofer USA Center for Molecular Biotechnology,undefined

[19] Newark,undefined

[20] Delaware,undefined

[21] USA (B.P.); Plant Pathology Department,undefined

[22] University of Florida,undefined

[23] Gainesville,undefined

[24] Florida,undefined

[25] USA (R.L.).,undefined

来源：

Nature Chemical Biology | 2012年 / 8卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The mechanism for nitro group formation in the thaxtomin family of natural products is unknown. Genetic and biochemical studies now show the cytochrome P450 TxtE catalyzes this direct and regioselective nitration, using NO and O2 to modify a tryptophan indole ring.[graphic not available: see fulltext]

引用

页码：814 / 816

页数：2

共 50 条

[1] Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis
Barry, Sarah M.
Kers, Johan A.
Johnson, Evan G.
Song, Lijiang
Aston, Philip R.
Patel, Bhumit
Krasnoff, Stuart B.
Crane, Brian R.
Gibson, Donna M.
Loria, Rosemary
Challis, Gregory L.
NATURE CHEMICAL BIOLOGY, 2012, 8 (10) : 814 - 816
[2] Cytochrome P450 catalyzed nitration of L-tryptophan
Barry, Sarah M.
Challis, Gregory L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[3] Involvement of a cytochrome P450 monooxygenase in thaxtomin a biosynthesis by Streptomyces acidiscabies
Healy, FG
Krasnoff, SB
Wach, M
Gibson, DM
Loria, R
JOURNAL OF BACTERIOLOGY, 2002, 184 (07) : 2019 - 2029
[4] Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis
Tsutsumi, Hayama
Katsuyama, Yohei
Izumikawa, Miho
Takagi, Motoki
Fujie, Manabu
Satoh, Noriyuki
Shin-ya, Kazuo
Ohnishi, Yasuo
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (21) : 6631 - 6639
[5] Strigolactone biosynthesis catalyzed by cytochrome P450 and sulfotransferase in sorghum
Yoda, Akiyoshi
Mori, Narumi
Akiyama, Kohki
Kikuchi, Mayu
Xie, Xiaonan
Miura, Kenji
Yoneyama, Kaori
Sato-Izawa, Kanna
Yamaguchi, Shinjiro
Yoneyama, Koichi
Nelson, David C.
Nomura, Takahito
NEW PHYTOLOGIST, 2021, 232 (05) : 1999 - 2010
[6] Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone
Fujiyama, Keisuke
Hino, Tomoya
Nagano, Shingo
BIOPHYSICS AND PHYSICOBIOLOGY, 2022, 19
[7] Biosynthesis of psoralen: Mechanism of a cytochrome p450 catalyzed oxidative bond cleavage
Stanjek, V
Miksch, M
Lueer, P
Matern, U
Boland, W
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1999, 38 (03) : 400 - 402
[8] Cytochrome P450 oxygenases of taxol biosynthesis
Kaspera R.
Croteau R.
Phytochemistry Reviews, 2006, 5 (2-3) : 433 - 444
[9] The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism
Haduch, Anna
Bromek, Ewa
Kuban, Wojciech
Daniel, Wladyslawa Anna
METABOLITES, 2023, 13 (05)
[10] Hole Hopping through Tryptophan in Cytochrome P450
Ener, Maraia E.
Gray, Harry B.
Winkler, Jay R.
BIOCHEMISTRY, 2017, 56 (28) : 3531 - 3538

← 1 2 3 4 5 →