Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry

Numerous diseases that cause blindness are associated with disrupted oxygen consumption in the retina, the part of the eye that senses light. This highlights the importance of accurately measuring oxygen consumption in the clinic. To address this challenge, we developed a method to analyze images of the retina which have been collected using visible-light optical coherence tomography, a non-invasive imaging method. Our approach achieves accurate oxygen level measurements in blood samples and in healthy volunteers. With further testing, our approach may prove useful in the clinical management of several diseases that cause blindness, allowing clinicians to more accurately diagnose disease and monitor the health of the eye.