The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing 2F5 HIV specific antibody

被引：0
|
作者：
Daniela Tudor
Anne-Sophie Drillet
Isabelle Schwartz-Cornil
Ruizhong Shen
Phillip D Smith
Morgane Bomsel
机构：
[1] Institut Cochin,
[2] INRA,undefined
[3] University of Birmingham,undefined
来源：
Retrovirology | / 7卷
关键词：
Neutralize Activity; ADCC Activity; Membrane Proximal Region; Heavy Chain Constant Region; Envelope Transmembrane;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing 2F5 HIV specific antibody
    Tudor, Daniela
    Drillet, Anne-Sophie
    Schwartz-Cornil, Isabelle
    Shen, Ruizhong
    Smith, Phillip D.
    Bomsel, Morgane
    RETROVIROLOGY, 2010, 7 : 22 - 22
  • [2] Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody
    Tudor, Daniela
    Yu, Huifeng
    Maupetit, Julien
    Drillet, Anne-Sophie
    Bouceba, Tahar
    Schwartz-Cornil, Isabelle
    Lopalco, Lucia
    Tuffery, Pierre
    Bomsel, Morgane
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (31) : 12680 - 12685
  • [3] How Tolerance Shapes the Development of the HIV-1 Broadly Neutralizing Antibody 2F5
    Finney, Joel T.
    Yang, Guang
    Kuraoka, Masayuki
    Nojima, Takuya
    Verkoczy, Laurent
    Kitamura, Daisuke
    Haynes, Barton F.
    Kelsoe, Garnett H.
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [4] Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures
    Sack, Markus
    Paetz, Antje
    Kunert, Renate
    Bomble, Michael
    Hesse, Friedemann
    Stiegler, Gabriela
    Fischer, Rainer
    Katinger, Hermann
    Stoeger, Eva
    Rademacher, Thomas
    FASEB JOURNAL, 2007, 21 (08): : 1655 - 1664
  • [5] Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5
    Finney, Joel
    Yang, Guang
    Kuraoka, Masayuki
    Song, Shengli
    Nojima, Takuya
    Verkoczy, Laurent
    Kitamura, Daisuke
    Haynes, Barton F.
    Kelsoe, Garnett
    JOURNAL OF IMMUNOLOGY, 2019, 203 (12): : 3268 - 3281
  • [6] De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope
    Viana, Isabelle Freire Tabosa
    Nascimento, Eduardo
    Craigo, Jodi
    Krieger, Marco
    Mailliard, Robbie
    Dhalia, Rafael
    Lins, Roberto
    Marques, Ernesto T. A.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 346A - 346A
  • [7] Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
    Julien, Jean-Philippe
    Bryson, Steve
    Nieva, Jose L.
    Pai, Emil F.
    JOURNAL OF MOLECULAR BIOLOGY, 2008, 384 (02) : 377 - 392
  • [8] Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
    Julien, Jean-Philippe
    Huarte, Nerea
    Maeso, Ruben
    Taneva, Stefka G.
    Cunningham, Annie
    Nieva, Jose L.
    Pai, Emil F.
    JOURNAL OF VIROLOGY, 2010, 84 (09) : 4136 - 4147
  • [9] Fusion Peptide Effects on Epitope Recognition At Membrane Surfaces by the Broadly Neutralizing Anti-HIV-1 2f5 Monoclonal Antibody
    Huarte, Nerea
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 91A - 91A
  • [10] Fusion peptide effects on epitope recognition at membrane surfaces by the broadly neutralizing anti-HIV-1 2F5 monoclonal antibody
    Huarte, Nerea
    Araujo, Aitziber
    Arranz, Rocio
    Valpuesta, Jose M.
    Nieva, Jose L.
    CHEMISTRY AND PHYSICS OF LIPIDS, 2010, 163 : S51 - S51
12345