How Tolerance Shapes the Development of the HIV-1 Broadly Neutralizing Antibody 2F5

被引:0
|
作者
Finney, Joel T. [1 ]
Yang, Guang [1 ]
Kuraoka, Masayuki [1 ]
Nojima, Takuya [1 ]
Verkoczy, Laurent [2 ]
Kitamura, Daisuke [3 ]
Haynes, Barton F. [1 ,2 ]
Kelsoe, Garnett H. [1 ,2 ]
机构
[1] Duke Univ, Durham, NC 27706 USA
[2] Duke Human Vaccine Inst, Durham, NC USA
[3] Tokyo Univ Sci, Tokyo 162, Japan
来源
JOURNAL OF IMMUNOLOGY | 2016年 / 196卷
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
146.16
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5
    Finney, Joel
    Yang, Guang
    Kuraoka, Masayuki
    Song, Shengli
    Nojima, Takuya
    Verkoczy, Laurent
    Kitamura, Daisuke
    Haynes, Barton F.
    Kelsoe, Garnett
    JOURNAL OF IMMUNOLOGY, 2019, 203 (12): : 3268 - 3281
  • [2] Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
    Yang, Guang
    Holl, T. Matt
    Liu, Yang
    Li, Yi
    Lu, Xiaozhi
    Nicely, Nathan I.
    Kepler, Thomas B.
    Alam, S. Munir
    Liao, Hua-Xin
    Cain, Derek W.
    Spicer, Leonard
    VandeBerg, John L.
    Haynes, Barton F.
    Kelsoe, Garnett
    JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (02): : 241 - 256
  • [3] Structural Constraints Imposed by the Conserved Fusion Peptide on the HIV-1 gp41 Epitope Recognized by the Broadly Neutralizing Antibody 2F5
    de la Arada, Igor
    Julien, Jean-Philippe
    de la Torre, Beatriz G.
    Huarte, Nerea
    Andreu, David
    Pai, Emil F.
    Arrondo, Jose L. R.
    Nieva, Jose L.
    JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 113 (41): : 13626 - 13637
  • [4] Immunological tolerance prevents the expression of a broadly reactive neutralizing HIV-1 antibody
    Verkoczy, L.
    Diaz, M.
    Holl, T. M.
    Ouyang, Y.
    Bouton-Verville, H.
    Alam, S. M.
    Liao, H.
    Kelsoe, G.
    Haynes, B. F.
    RETROVIROLOGY, 2009, 6
  • [5] De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope
    Viana, Isabelle Freire Tabosa
    Nascimento, Eduardo
    Craigo, Jodi
    Krieger, Marco
    Mailliard, Robbie
    Dhalia, Rafael
    Lins, Roberto
    Marques, Ernesto T. A.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 346A - 346A
  • [6] Structure-guided Alterations of the gp41-directed HIV-1 Broadly Neutralizing Antibody 2F5 Reveal New Properties Regarding its Neutralizing Function
    Guenaga, Javier
    Wyatt, Richard T.
    PLOS PATHOGENS, 2012, 8 (07): : 28
  • [7] Determinants of HIV-1 broadly neutralizing antibody induction
    Rusert, Peter
    Kouyos, Roger D.
    Kadelka, Claus
    Ebner, Hanna
    Schanz, Merle
    Huber, Michael
    Braun, Dominique L.
    Hoze, Nathanael
    Scherrer, Alexandra
    Magnus, Carsten
    Weber, Jacqueline
    Uhr, Therese
    Cippa, Valentina
    Thorball, Christian W.
    Kuster, Herbert
    Cavassini, Matthias
    Bernasconi, Enos
    Hoffmann, Matthias
    Calmy, Alexandra
    Battegay, Manuel
    Rauch, Andri
    Yerly, Sabine
    Aubert, Vincent
    Klimkait, Thomas
    Boni, Jurg
    Fellay, Jacques
    Regoes, Roland R.
    Gunthard, Huldrych F.
    Trkola, Alexandra
    NATURE MEDICINE, 2016, 22 (11) : 1260 - 1267
  • [8] Determinants of HIV-1 broadly neutralizing antibody induction
    Peter Rusert
    Roger D Kouyos
    Claus Kadelka
    Hanna Ebner
    Merle Schanz
    Michael Huber
    Dominique L Braun
    Nathanael Hozé
    Alexandra Scherrer
    Carsten Magnus
    Jacqueline Weber
    Therese Uhr
    Valentina Cippa
    Christian W Thorball
    Herbert Kuster
    Matthias Cavassini
    Enos Bernasconi
    Matthias Hoffmann
    Alexandra Calmy
    Manuel Battegay
    Andri Rauch
    Sabine Yerly
    Vincent Aubert
    Thomas Klimkait
    Jürg Böni
    Jacques Fellay
    Roland R Regoes
    Huldrych F Günthard
    Alexandra Trkola
    Nature Medicine, 2016, 22 : 1260 - 1267
  • [10] Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody
    Tudor, Daniela
    Yu, Huifeng
    Maupetit, Julien
    Drillet, Anne-Sophie
    Bouceba, Tahar
    Schwartz-Cornil, Isabelle
    Lopalco, Lucia
    Tuffery, Pierre
    Bomsel, Morgane
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (31) : 12680 - 12685