4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2- oxo-1,2-dihydroquinolines with anilines

被引：0
|
作者：
Ukrainets I.V. [1 ]
Sidorenko L.V. [1 ]
Gorokhova O.V. [1 ]
Jaradat N.A. [2 ]
机构：
[1] National Pharmaceutical University
[2] An-Najah National University College of Pharmacy, Nablus
来源：
Chemistry of Heterocyclic Compounds | 2006年 / 42卷 / 3期
关键词：
4-arylamino-2-oxo-1,2-dihydroquinolines; Anti-inflammatory activity; Decarboxylation; X-ray structural analysis;
D O I：
10.1007/s10593-006-0091-5
中图分类号：
学科分类号：
摘要：
A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1, 2-dihydroquinolines has been effected. An X-ray structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried out enabling the ease of decarboxylating such compounds to be substantiated. Results are given of a study of the anti-inflammatory activity of the synthesized compounds. ©2006 Springer Science+Business Media, Inc.
引用
收藏
页码：343 / 351
页数：8
相关论文
共 50 条
  • [21] 4-Hydroxy-2-quinolones 119. Reaction of ethyl 1-R-4-chloro-2-oxo-1,2- dihydroquinoline-3-carboxylate with malononitrile
    Ukrainets I.V.
    Bereznyakova N.L.
    Parshikov V.A.
    Shishkina S.V.
    Chemistry of Heterocyclic Compounds, 2007, 43 (6) : 722 - 728
  • [22] 4-Hydroxy-2-quinolones. 34. Structure of photocondensation products of 3-amino-1R-2-oxo-4-hydroxyquinolines
    Ukrainets I.V.
    Taran S.G.
    Sidorenko L.V.
    Gorokhova O.V.
    Turov A.V.
    Ogirenko A.A.
    Chemistry of Heterocyclic Compounds, 1997, 33 (7) : 815 - 822
  • [23] 4-Hydroxy-2-quinolones. 46. Esters of 1h-2-oxo-4-hydroxy-3-quinolineacetic acid
    Ukrainets I.V.
    Kamenetskaya O.L.
    Taran S.G.
    Petukhova I.Y.
    Voronina L.N.
    Chemistry of Heterocyclic Compounds, 2001, 37 (01) : 100 - 102
  • [24] 4-Hydroxy-2-quinolones. 152*. 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline and its biologically active derivatives
    I. V. Ukrainets
    A. A. Tkach
    Liu Yang Yang
    Chemistry of Heterocyclic Compounds, 2009, 45 : 169 - 175
  • [25] 4-Hydroxy-2-quinolones. 43. Thermolysis of ethyl esters of 1-R-2-oxo-4-hydroxy-quinoline-3-carboxylic acids
    Ukrainets I.V.
    Taran E.A.
    Shishkin O.V.
    Gorokhova O.V.
    Taran S.G.
    Jaradat N.A.
    Turov A.V.
    Chemistry of Heterocyclic Compounds, 2000, 36 (04) : 443 - 448
  • [26] 4-Hydroxy-2-quinolones. 167*. Study of the reaction of ethyl 1-alkyl-substituted 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates with phosphorus oxychloride
    Ukrainets, I. V.
    Bereznyakova, N. L.
    Davidenko, A. A.
    Slobodzian, S. V.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (08) : 952 - 956
  • [27] REACTIONS OF 1,2-DIHYDROQUINOLINES .4. INTERACTION OF 2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINES WITH CYCLOHEXANE
    LUGOVIK, BA
    BORODIN, PV
    YUDIN, LG
    BUDYLIN, VA
    KOST, AN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1971, (07): : 977 - &
  • [28] 4-hydroxy-2-quinolones. 30. Alkylation of 1H-2-oxo-3-carbethoxy-4-hydroxyquinoline
    Ukrainian Pharmaceutical Academy, Khar'kov 310002, Ukraine
    Chem. Heterocycl. Compd., 8 (952-959):
  • [29] 4-Hydroxy-2-quinolones. 91. Synthesis and properties of ethyl 1-R-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-5-carboxylates
    Ukrainets, IV
    Sidorenko, LV
    Gorokhova, OV
    Shishkin, OV
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (02): : 217 - 223
  • [30] 4-Hydroxy-2-quinolones. 132. Synthesis, chemical and biological properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids of 2-nitrobenzylidenehydrazides
    Ukrainets, I. V.
    Sidorenko, L. V.
    Golovchenko, O. S.
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2007, (11): : 1687 - 1692
12345