Nm-seq maps 2′-O-methylation sites in human mRNA with base precision

被引：0

作者：

Qing Dai

Sharon Moshitch-Moshkovitz

Dali Han

Nitzan Kol

Ninette Amariglio

Gideon Rechavi

Dan Dominissini

Chuan He

机构：

[1] The University of Chicago,Department of Chemistry

[2] Howard Hughes Medical Institute,Department of Biochemistry and Molecular Biology

[3] The University of Chicago,undefined

[4] Cancer Research Center,undefined

[5] Chaim Sheba Medical Center,undefined

[6] Wohl Centre for Translational Medicine,undefined

[7] Chaim Sheba Medical Center,undefined

[8] The Mina and Everard Goodman Faculty of Life Sciences,undefined

[9] Bar-Ilan University,undefined

[10] Sackler School of Medicine,undefined

[11] Tel Aviv University,undefined

[12] The University of Chicago,undefined

[13] Institute for Biophysical Dynamics,undefined

[14] The University of Chicago,undefined

来源：

Nature Methods | 2017年 / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Iterative oxidation, elimination and dephosphorylation steps remove nucleotides from the 3′ end of RNA until a 2′-O-methylated ribose that cannot be oxidized is encountered and brings the process to a stop. High-throughput sequencing of these fragments exposes 2′-O-methyl sites at base resolution.

引用

页码：695 / 698

页数：3

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