Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

被引：0
|
作者：
Steven J. Smith
Gary T. Pauly
Aamir Akram
Kevin Melody
Ganesha Rai
David J. Maloney
Zandrea Ambrose
Craig J. Thomas
Joel T. Schneider
Stephen H. Hughes
机构：
[1] National Institutes of Health,HIV Drug Resistance Program, National Cancer Institute
[2] National Institutes of Health,Frederick
[3] University of Pittsburgh,Chemical Biology Laboratory, National Cancer Institute
[4] University of Pittsburgh,Frederick
[5] NIH,Department of Infectious Diseases and Microbiology, Graduate School of Public Health
来源：
Retrovirology | / 13卷
关键词：
HIV-1; Nonnucleoside reverse transcriptase inhibitors; Rilpivirine; Antiviral activity; Resistance; Analogs; Susceptibility; Binding pocket; Doravirine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Drug resistance: crystallography of drug-resistant HIV-1 protease mutant
    Raskar, Tushar
    Das, Amit
    Hosur, M. V.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2015, 33 : 124 - 124
  • [22] Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise
    Hollander, Klarissa
    Chan, Albert H.
    Frey, Kathleen M.
    Hunker, Olivia
    Ippolito, Joseph A.
    Spasov, Krasimir A.
    Yeh, Yang-Hui J.
    Jorgensen, William L.
    Ho, Ya-Chi
    Anderson, Karen S.
    PROTEIN SCIENCE, 2023, 32 (12)
  • [23] Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases
    Sarafianos, SG
    Das, K
    Hughes, SH
    Arnold, E
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (06) : 716 - 730
  • [24] KINETIC-ANALYSIS OF MUTANT HIV-1 PROTEINASES - FUNCTIONAL-ANALYSIS OF DRUG-RESISTANT MUTANTS
    DUNN, BM
    LEELAMANIT, W
    RATERMAN, D
    LIN, YZ
    LIN, XL
    TANG, J
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 129 - 129
  • [25] Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
    Marinello, Jessica
    Marchand, Christophe
    Mott, Bryan T.
    Bain, Anjali
    Thomas, Craig J.
    Pommier, Yves
    BIOCHEMISTRY, 2008, 47 (36) : 9345 - 9354
  • [26] Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants
    Smith, Steven J.
    Pauly, Gary T.
    Akram, Aamir
    Melody, Kevin
    Ambrose, Zandrea
    Schneider, Joel P.
    Hughes, Stephen H.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2016, 72 (05) : 485 - 491
  • [27] Sexual transmission of an extensively drug-resistant HIV-1 strain
    Raymond, Stephanie
    Piffaut, Marie
    Bigot, Jonathan
    Cazabat, Michelle
    Montes, Brigitte
    Bertrand, Kevin
    Martin-Blondel, Guillaume
    Izopet, Jacques
    Delobel, Pierre
    LANCET HIV, 2020, 7 (08): : E529 - E530
  • [28] Transmission of drug-resistant strains of HIV-1: unfortunate, but inevitable
    Cohen, OJ
    Fauci, AS
    LANCET, 1999, 354 (9180): : 697 - 698
  • [29] Declining trend in transmission of drug-resistant HIV-1 in Amsterdam
    Bezemer, D
    Jurriaans, S
    Prins, M
    van der Hoek, L
    Prins, JM
    de Wolf, F
    Berkhout, B
    Coutinho, R
    Back, NKT
    AIDS, 2004, 18 (11) : 1571 - 1577
  • [30] Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
    Li, Na
    Wang, Yuxuan
    Pothukuchy, Arti
    Syrett, Angel
    Husain, Naeem
    Gopalakrisha, Siddharth
    Kosaraju, Pradeepa
    Ellington, Andrew D.
    NUCLEIC ACIDS RESEARCH, 2008, 36 (21) : 6739 - 6751
12345