Effects of partial hepatectomy on the plasma membrane status and the invertor mechanism of the hepatocyte Na,K-ATPase activity regulation in rats of various age

被引：0
|
作者：
V. V. Frolkis
A. L. Kobzar
O. V. Sokolova
机构：
[1] Institute of Gerontology AMS of Ukraine,Laboratory of Physiology
[2] Academy of Medical Sciences of Ukraine,Institute of Gerontology
来源：
Aging Clinical and Experimental Research | 1999年 / 11卷
关键词：
Aging; insulin; invertors; Na; K-ATPase; partial hepatectomy; rats;
D O I：
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学科分类号：
摘要：
The experiments were performed on adult (6–8 months) and old (22–24 months) Wistar rats. Insulin induced plasma membrane hyperpolarization and hepatocyte Na,K-ATPase activation in adult but not in old sham-operated rats. Partial hepatectomy had no effect on the invertor mechanism of Na,K-ATPase activity regulation in the liver of adult rats, while pronounced changes took place in old animals 4 weeks after partial hepatectomy. Insulin induced hyperpolarization in hepatocyte plasma membrane and activation of Na,K-ATPase both in old and adult hepatectomized rats. Invertors, intracellular regulators of the plasma membrane status, played an important role in the mechanism of this insulin-induced hyperpolarization. Four weeks after partial hepatectomy in old animals, the invertor mechanism of hepatocyte plasma membrane regulation appeared again, as well as membrane Na,K-ATPase capability to react to insulin action. (Aging Clin. Exp. Res. 11: 130-134, 1999)
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页码：130 / 134
页数：4
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