Potentin Vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomyceteSac-charopolyspora sp. nov.

被引：0
|
作者：
Rui Liu
Cheng-Bin Cui
Lin Duan
Qian-Qun Gu
Wei-Ming Zhu
机构：
[1] Beijing Institute of Pharmacology and Toxicology,AMMS
[2] Ocean University of China,Key Laboratory of Marine Drugs, Chinese Ministry of Education; Institute of Marine Drugs and Food
来源：
Archives of Pharmacal Research | 2005年 / 28卷
关键词：
Mycale plumose; Sponge-derived actinomycete; sp. nov; Metacycloprodigiosin; Undecylprodigiosin; Tripyrrole pigments; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Bioassay-guided fractionation of CHCI3 extract from the fermentation broth of a spongeMycale plumose-derived actinomyceteSaccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1 ) against human cancer cell lines.
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页码：1341 / 1344
页数：3
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