Stachylines A-D from the Sponge-Derived Fungus Stachylidium sp.

被引:43
|
作者
Almeida, Celso [1 ]
Part, Natalja [1 ]
Bouhired, Sarah [1 ]
Kehraus, Stefan [1 ]
Koenig, Gabriele M. [1 ]
机构
[1] Univ Bonn, Inst Pharmaceut Biol, D-53115 Bonn, Germany
来源
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 01期
关键词
ACTIVE SECONDARY METABOLITES; NATURAL-PRODUCTS; NOCARDICIN-A; ACID; BIOSYNTHESIS; ASSAY; INHIBITION; TYROSINE; OXIME; NOCL;
D O I
10.1021/np1005345
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.
引用
收藏
页码:21 / 25
页数:5
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