Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

被引：9
|
作者：
El Maddah, Fayrouz [1 ,2 ]
Eguereva, Ekaterina [1 ]
Kehraus, Stefan [1 ]
Koenig, Gabriele M. [1 ]
机构：
[1] Univ Bonn, Inst Pharmaceut Biol, Nussallee 6, D-53115 Bonn, Germany
[2] Natl Org Drug Control & Res, Dept Pharmacognosy & Tissue Culture, Cairo, Egypt
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 10期
关键词：
A-C; METABOLITES; ACID; PROPIONATE; PRODUCTS; PHTHALIDES; PATHWAY; ORIGIN;
D O I：
10.1039/c9ob00198k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using C-13-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.
引用
收藏
页码：2747 / 2752
页数：6
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