Polycyclic systems containing 1,2,4-oxadiazole ring 2. 4-(1,2,4-Oxadiazol-5-yl)pyrrolidin-2-ones: Synthesis and prediction of biological activity

被引：0
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作者：
Yu. V. Kharchenko
O. S. Detistov
V. D. Orlov
机构：
[1] V. N. Karazin National University,
来源：
Chemistry of Heterocyclic Compounds | 2008年 / 44卷
关键词：
1,2,4-oxadiazole; pyrrolidin-2-one; biological activity; one-pot synthesis;
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学科分类号：
摘要：
A one-pot condensation of 5-oxopyrrolidine-3-carboxylic acids, carbonyldiimidazole, and benzamidoximes leads to the formation of the novel 4-(1,2,4-oxadiazol-5-yl)pyrrolidin-2-one bicyclic systems, the structures of which have been confirmed by IR and 1H NMR methods and by liquid chromato-mass spectrometry. The results of a PASS prediction of the biological activity of the synthesized compounds are presented.
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