The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

被引：0

作者：

Yuuki Obata

Yukihiro Furusawa

Takaho A Endo

Jafar Sharif

Daisuke Takahashi

Koji Atarashi

Manabu Nakayama

Satoshi Onawa

Yumiko Fujimura

Masumi Takahashi

Tomokatsu Ikawa

Takeshi Otsubo

Yuki I Kawamura

Taeko Dohi

Shoji Tajima

Hiroshi Masumoto

Osamu Ohara

Kenya Honda

Shohei Hori

Hiroshi Ohno

Haruhiko Koseki

Koji Hase

机构：

[1] International Research and Development Center for Mucosal Vaccines,Division of Mucosal Barriology

[2] The Institute of Medical Science,Department of Human Genome Research

[3] The University of Tokyo,Department of Gastroenterology

[4] Laboratory for Immune Regulation,Department of Frontier Research

[5] Graduate School of Medicine,undefined

[6] Chiba University,undefined

[7] Laboratory for Bioenvironmental Epigenetics,undefined

[8] RIKEN Center for Integrative Medical Sciences,undefined

[9] Graduate School of Medical Life Science,undefined

[10] Yokohama City University,undefined

[11] Laboratory for Integrative Genomics,undefined

[12] RIKEN Center for Integrative Medical Sciences,undefined

[13] Laboratory for Developmental Genetics,undefined

[14] RIKEN Center for Integrative Medical Sciences,undefined

[15] Laboratory for Intestinal Ecosystem,undefined

[16] RIKEN Center for Integrative Medical Sciences,undefined

[17] Laboratory for Gut Homeostasis,undefined

[18] RIKEN Center for Integrative Medical Sciences,undefined

[19] PRESTO,undefined

[20] Japan Science and Technology Agency,undefined

[21] Laboratory of Medical Genomics,undefined

[22] Kazusa DNA Research Institute,undefined

[23] Laboratory for Immune Regeneration,undefined

[24] RIKEN Center for Integrative Medical Sciences,undefined

[25] Research Center for Hepatitis and Immunology,undefined

[26] Research Institute,undefined

[27] National Center for Global Health and Medicine,undefined

[28] Laboratory of Epigenetics,undefined

[29] Institute for Protein Research,undefined

[30] Osaka University,undefined

[31] Laboratory of Cell Engineering,undefined

[32] Kazusa DNA Research Institute,undefined

[33] CREST,undefined

[34] Japan Science and Technology Agency,undefined

[35] Laboratory for Immune Homeostasis,undefined

[36] RIKEN Center for Integrative Medical Sciences,undefined

[37] Present address: Department of Biochemistry,undefined

[38] Keio University Graduate School of Pharmaceutical Science,undefined

[39] Tokyo,undefined

[40] Japan.,undefined

来源：

Nature Immunology | 2014年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Regulatory T cells proliferate robustly in gut lymphoid tissues. Hase et al. show that this proliferation requires their expression of the epigenetic regulator Uhrf1, which is increased in response to IL-2 produced by effector T cells.

引用

页码：571 / 579

页数：8

共 50 条

[21] Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration
Oh, Young Mi
Mahar, Marcus
Ewan, Eric E.
Leahy, Kathleen M.
Zhao, Guoyan
Cavalli, Valeria
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (52) : E12417 - E12426
[22] Upregulation of UHRF1 promotes the progression of melanoma by inducing cell proliferation
Wei, Chuanyuan
Lu, Nanhang
Wang, Lu
Zhang, Yong
Feng, Zihao
Yang, Yanwen
Qi, Fazhi
Gu, Jianying
ONCOLOGY REPORTS, 2018, 39 (06) : 2553 - 2562
[23] Epigenetic Modifier UHRF1 May Be a Potential Target in Malignant Pleural Mesothelioma
Baird, Anne-Marie
Finn, Stephen P.
Gray, Steven G.
Sheils, Orla
JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (01) : 14 - 16
[24] The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein
D Guan
D Factor
Yu Liu
Z Wang
H-Y Kao
Oncogene, 2013, 32 : 3819 - 3828
[25] Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
Arita, Kyohei
Isogai, Shin
Oda, Takashi
Unoki, Motoko
Sugita, Kazuya
Sekiyama, Naotaka
Kuwata, Keiko
Hamamoto, Ryuji
Tochio, Hidehito
Sato, Mamoru
Ariyoshi, Mariko
Shirakawa, Masahiro
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) : 12950 - 12955
[26] The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein
Guan, D.
Factor, D.
Liu, Yu
Wang, Z.
Kao, H-Y
ONCOGENE, 2013, 32 (33) : 3819 - 3828
[27] Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis
Chengkui Yang
Jun Li
Lu Yu
Zili Zhang
Feng Xu
Lang Jiang
Xiuxia Zhou
Sudan He
Cell Death & Disease, 2017, 8 : e3084 - e3084
[28] Regulatory T Cell-Specific Uhrf1 Deficiency Leads To Spontaneous Lymphoproliferative Lung Inflammation
Singer, B. D.
Helmin, K.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
[29] UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer
Kofunato, Yasuhide
Kumamoto, Kensuke
Saitou, Katsuharu
Hayase, Suguru
Okayama, Hirokazu
Miyamoto, Kotaro
Sato, Yu
Katakura, Kyoko
Nakamura, Izumi
Ohki, Shinji
Koyama, Yoshihisa
Unoki, Motoko
Takenoshita, Seiichi
ONCOLOGY REPORTS, 2012, 28 (06) : 1997 - 2002
[30] Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis
Bronner, Christian
Krifa, Mounira
Mousli, Marc
BIOCHEMICAL PHARMACOLOGY, 2013, 86 (12) : 1643 - 1649

← 1 2 3 4 5 →