The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

被引：0

作者：

Yuuki Obata

Yukihiro Furusawa

Takaho A Endo

Jafar Sharif

Daisuke Takahashi

Koji Atarashi

Manabu Nakayama

Satoshi Onawa

Yumiko Fujimura

Masumi Takahashi

Tomokatsu Ikawa

Takeshi Otsubo

Yuki I Kawamura

Taeko Dohi

Shoji Tajima

Hiroshi Masumoto

Osamu Ohara

Kenya Honda

Shohei Hori

Hiroshi Ohno

Haruhiko Koseki

Koji Hase

机构：

[1] International Research and Development Center for Mucosal Vaccines,Division of Mucosal Barriology

[2] The Institute of Medical Science,Department of Human Genome Research

[3] The University of Tokyo,Department of Gastroenterology

[4] Laboratory for Immune Regulation,Department of Frontier Research

[5] Graduate School of Medicine,undefined

[6] Chiba University,undefined

[7] Laboratory for Bioenvironmental Epigenetics,undefined

[8] RIKEN Center for Integrative Medical Sciences,undefined

[9] Graduate School of Medical Life Science,undefined

[10] Yokohama City University,undefined

[11] Laboratory for Integrative Genomics,undefined

[12] RIKEN Center for Integrative Medical Sciences,undefined

[13] Laboratory for Developmental Genetics,undefined

[14] RIKEN Center for Integrative Medical Sciences,undefined

[15] Laboratory for Intestinal Ecosystem,undefined

[16] RIKEN Center for Integrative Medical Sciences,undefined

[17] Laboratory for Gut Homeostasis,undefined

[18] RIKEN Center for Integrative Medical Sciences,undefined

[19] PRESTO,undefined

[20] Japan Science and Technology Agency,undefined

[21] Laboratory of Medical Genomics,undefined

[22] Kazusa DNA Research Institute,undefined

[23] Laboratory for Immune Regeneration,undefined

[24] RIKEN Center for Integrative Medical Sciences,undefined

[25] Research Center for Hepatitis and Immunology,undefined

[26] Research Institute,undefined

[27] National Center for Global Health and Medicine,undefined

[28] Laboratory of Epigenetics,undefined

[29] Institute for Protein Research,undefined

[30] Osaka University,undefined

[31] Laboratory of Cell Engineering,undefined

[32] Kazusa DNA Research Institute,undefined

[33] CREST,undefined

[34] Japan Science and Technology Agency,undefined

[35] Laboratory for Immune Homeostasis,undefined

[36] RIKEN Center for Integrative Medical Sciences,undefined

[37] Present address: Department of Biochemistry,undefined

[38] Keio University Graduate School of Pharmaceutical Science,undefined

[39] Tokyo,undefined

[40] Japan.,undefined

来源：

Nature Immunology | 2014年 / 15卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Regulatory T cells proliferate robustly in gut lymphoid tissues. Hase et al. show that this proliferation requires their expression of the epigenetic regulator Uhrf1, which is increased in response to IL-2 produced by effector T cells.

引用

页码：571 / 579

页数：8

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