A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2–q12.3

被引：0
|
作者：
Arunima Chatterjee
Rajeev Jalvi
Nishtha Pandey
R. Rangasayee
Anuranjan Anand
机构：
[1] Jawaharlal Nehru Centre for Advanced Scientific Research,Molecular Biology and Genetics Unit
[2] Ali Yavar Jung National Institute for the Hearing Handicapped,undefined
来源：
Human Genetics | 2009年 / 124卷
关键词：
Hearing Loss; Genetic Interval; Nonsyndromic Hearing Loss; Hereditary Hearing Loss; Protein Interaction Prediction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Autosomal dominant nonsyndromic hearing loss (ADNSHL) accounts for about one-fifth of hereditary hearing loss in humans. In the present study, we have analyzed a three-generation family with 14 of its members manifesting ADNSHL, using a genome-wide linkage mapping approach. We found a novel locus DFNA59 between the D11S929 and D11S480 markers in the chromosome location 11p14.2–q12.3. The highest two-point lod score of 5.72 at recombination fraction = 0 was obtained for D11S4152, D11S4154, D11S1301, D11S905 and D11S1344. The critical genomic region comprising about 37 megabases of DNA is proposed to carry a gene for ADNSHL in the family. About 50 cochlear-expressed genes mapping to the region are strong candidates which we propose to examine to identify the gene responsible for the hearing impairment.
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页码：669 / 675
页数：6
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