Peroxisome Proliferator-Activated Receptor Gamma (PPARγ as a Novel Target for Prostate Cancer

被引：0
|
作者：
Matthew R. Smith
Philip W. Kantoff
机构：
[1] Massachusetts General Hospital,
[2] Dana Farber Cancer Institute,undefined
来源：
Investigational New Drugs | 2002年 / 20卷
关键词：
peroxisome proliferator-activated receptor gamma (PPARγ); prostatic neoplasm;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peroxisome proliferator activatedreceptor-gamma (PPARγ) is a memberof the nuclear receptor superfamily ofligand-activated transcription factors. PPARγ is expressed at high levels inadipose tissue and plays a central role inadipocyte differentiation. Recent studieshave implicated PPARγ in thepathogenesis of several human malignancies.Here we review the evidence thatPPARγ contributes to prostatecarcinogenesis and the potential forPPARγ as a novel therapeutic targetfor prostate cancer.
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页码：195 / 200
页数：5
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