Synthesis of pyrrolo[2,3-d]pyrimidines with 3-amino-2-hydroxypropyl substituents

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作者
L. V. Muzychka
E. V. Verves
I. O. Yaremchuk
O. B. Smolii
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[1] Ukraine National Academy of Sciences,Institute of Bioorganic and Petroleum Chemistry
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关键词
pyrimido[5',4':4,5]pyrrolo[2,1-; ][1,4]oxazines; pyrrolo[2,3-; ]pyrimidines; bromolacto-nization;
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摘要
A novel route has been found for the synthesis of pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines. They are promising reagents for the preparation of pyrrolo[2,3-d]pyrimidine-6-carboxylic acid amides which contain a 3-amino-2-hydroxypropyl substituent in position 7 of the heterocyclic ring.
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页码:481 / 487
页数:6
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