Identification of silver nanoparticles in the small intestinal mucosa, liver, and spleen of rats by transmission electron microscopy

被引：0

作者：

Platonova T.A. ^{[1
]}

Pridvorova S.M. ^{[1
]}

Zherdev A.V. ^{[1
]}

Vasilevskaya L.S. ^{[2
]}

Arianova E.A. ^{[2
]}

Gmoshinski I.V. ^{[2
]}

Khotimchenko S.A. ^{[2
]}

Dzantiev B.B. ^{[1
]}

Popov V.O. ^{[1
]}

Tutelyan V.A. ^{[2
]}

机构：

[1] A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow

[2] Institute of Nutrition, Russian Academy of Medical Sciences, Moscow

来源：

Bulletin of Experimental Biology and Medicine | 2013年 / 155卷 / 2期

关键词：

electron microscopy; liver; nanoparticles; small intestine; spleen;

D O I：

10.1007/s10517-013-2122-4

中图分类号：

学科分类号：

摘要：

The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and splenic tissues. Ultrastructural changes (lobed nucleus, megamitochondria) were found in the studied organs. These data indicated that injection of waterdispersed Ag nanoparticles into the gastrointestinal tract was followed by their penetration through the epithelium of the small intestinal mucosa into other organs, e.g. into the liver and spleen. This fact is essential for evaluation of potential risks of the nanoparticle effects on human health and environment. © 2013 Springer Science+Business Media New York.

引用

页码：236 / 241

页数：5

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