Regulatory T cells in HIV infection: Who's suppressing what?

被引：8
|
作者：
Seddiki N. [1 ]
Kelleher A.D. [1 ]
机构：
[1] Centre for Immunology, Saint Vincent's Hospital, Darlinghurst
来源：
Current Infectious Disease Reports | 2008年 / 10卷 / 3期
关键词：
Foxp3 Expression; Treg Function; Foxp3 mRNA; Treg Number; Treg Subset;
D O I：
10.1007/s11908-008-0041-8
中图分类号：
学科分类号：
摘要：
The role of regulatory T cells (Treg) in HIV pathogenesis is not fully elucidated. Persistent antigens such as HIV are believed to promote the expansion and activation of antigen-specific Treg, and several reports have described beneficial and detrimental roles for Treg in HIV pathogenesis. These apparently contradictory observations may arise from imprecision in enumerating Treg and the lack of definition of Treg subsets. New markers allowing more precise identification and purification of Treg for functional studies have been described recently, and these may open avenues for efficient isolation of pure, homogenous populations of human Treg. Copyright © 2008 by Current Medicine Group LLC.
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页码：252 / 258
页数：6
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