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Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Marlene & Stewart Greenebaum Canc Ctr, 655 West Baltimore St, Baltimore, MD 21201 USA Univ Calif Merced, Program Quantitat Syst Biol, Syst Biol & Canc Metab, 2500 North Lake Rd, Merced, CA 95343 USA