Malarone treatment failure not associated with previously described mutations in the cytochrome b gene

被引：0
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作者：
Ole Wichmann
Marion Muehlen
Holger Gruss
Frank P Mockenhaupt
Norbert Suttorp
Tomas Jelinek
机构：
[1] Charité,Institute of Tropical Medicine
[2] Humboldt University,undefined
[3] Virchow Klinikum,undefined
[4] Charité,undefined
[5] Humboldt University,undefined
来源：
Malaria Journal | / 3卷
关键词：
Malaria Parasite; Parasite Density; Artemether; Atovaquone; Proguanil;
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学科分类号：
摘要：
Malarone® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone® treatment failure from Central Africa.
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