Fishing for missing heritability in IBD

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作者
Michael Pack
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[1] Perelman School of Medicine,Department of Medicine and Cell and Developmental Biology
[2] University of Pennsylvania,undefined
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摘要
A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the 'missing heritability' of IBD.
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页码:318 / 320
页数:2
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