Energetic role of the paddle motif in voltage gating of Shaker K+ channels

被引：0
|
作者：
Yanping Xu
Yajamana Ramu
Hyeon-Gyu Shin
Jayden Yamakaze
Zhe Lu
机构：
[1] Howard Hughes Medical Institute,Department of Physiology
[2] University of Pennsylvania Perelman School of Medicine,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
In voltage-gated ion channels, transmembrane segments S3 and S4 are involved in voltage sensing and adopt a helix-turn-helix conformation, called the paddle motif, in crystal structures. Now extensive mutagenesis and electrophysiology analyses of the Shaker K+ channel demonstrate the physiological relevance of the paddle motif and dissect the roles of each segment in voltage sensing.
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页码：574 / 581
页数：7
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