Energetic role of the paddle motif in voltage gating of Shaker K+ channels

被引：0

作者：

Yanping Xu

Yajamana Ramu

Hyeon-Gyu Shin

Jayden Yamakaze

Zhe Lu

机构：

[1] Howard Hughes Medical Institute,Department of Physiology

[2] University of Pennsylvania Perelman School of Medicine,undefined

来源：

Nature Structural & Molecular Biology | 2013年 / 20卷

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D O I：

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学科分类号：

摘要：

In voltage-gated ion channels, transmembrane segments S3 and S4 are involved in voltage sensing and adopt a helix-turn-helix conformation, called the paddle motif, in crystal structures. Now extensive mutagenesis and electrophysiology analyses of the Shaker K+ channel demonstrate the physiological relevance of the paddle motif and dissect the roles of each segment in voltage sensing.

引用

页码：574 / 581

页数：7

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