The role of striatal metabotropic glutamate receptors in Parkinson's disease

被引：0
|
作者：
K. Ossowska
J. Konieczny
J. Wardas
K. Gołembiowska
S. Wolfarth
A. Pilc
机构：
[1]  Department of Neuro-Psychopharmacology,
[2] Institute of Pharmacology,undefined
[3] ,undefined
[4]  Department of Pharmacology,undefined
[5] Institute of Pharmacology,undefined
[6] and,undefined
[7]  Department of Neurobiology,undefined
[8] Institute of Pharmacology,undefined
[9] Polish Academy of Sciences,undefined
[10] Kraków,undefined
[11] Poland,undefined
来源：
Amino Acids | 2002年 / 23卷
关键词：
Keywords: Metabotropic glutamate receptors; Antiparkinsonian-like effects; Striatum;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 The primary cause of Parkinson's disease is a loss of dopamine in the corpus striatum. It has been postulated that this effect leads to disinhibition of the striopallidal pathway and secondarily, to a functional shift towards glutamatergic stimulation. The aim of the present study was to find out whether inhibition of glutamatergic transmission at a level of metabotropic glutamate receptors (mGluRs) in the striatum may alleviate parkinsonian-like symptoms in rats.
引用
收藏
页码：193 / 198
页数：5
相关论文
共 50 条
  • [31] The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer’s disease
    Vicky W. -W. Tsai
    Heather L. Scott
    Richard J. Lewis
    Peter R. Dodd
    Neurotoxicity Research, 2005, 7 : 125 - 141
  • [32] Role of metabotropic glutamate receptors in nociception
    Maione, S
    Palazzo, E
    Oliva, P
    Marabese, I
    Liguori, G
    Rossi, FS
    Riccio, MR
    Rossi, F
    NEUROPHARMACOLOGY, 1999, 38 (10) : A48 - A48
  • [33] Pharmacological regulation of striatal gene expression by metabotropic glutamate receptors
    Wang, JQ
    Mao, LM
    ACTA PHARMACOLOGICA SINICA, 1999, 20 (07) : 577 - 584
  • [34] Metabotropic glutamate receptors modulate striatal quinolinic acid toxicity
    Orlando, LR
    Kosinski, CM
    Kerner, JA
    Testa, CM
    Standaert, DG
    Penney, JB
    Young, AB
    METABOTROPIC GLUTAMATE RECEPTORS AND BRAIN FUNCTION, 1998, 12 : 79 - 86
  • [35] The role of metabotropic glutamate receptors in neurogenesis
    Ollivier, May Lissa
    Emond, Martine P.
    Lema, Pablo
    Carmant, Lionel
    EPILEPSIA, 2006, 47 : 229 - 229
  • [36] Effects of the blockade of subtype 1 metabotropic glutamate receptors (mGIuRs) in models of Parkinson's disease in the rat
    Ossowska, K
    Wardas, J
    Konieczny, J
    Pietraszek, M
    Zapala, M
    Wolfarth, S
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2002, 12 : S370 - S370
  • [37] Type-3 Metabotropic Glutamate Receptors and Parkinson's Disease: Preclinical Studies and Human Genetics
    Alborghetti, M.
    Di Menna, L.
    Traficante, A.
    Bruno, V.
    Monn, J.
    Nicoletti, F.
    Pontieri, F. E.
    Bianchini, E.
    Spalletta, G.
    Borro, M.
    Simmaco, M.
    Battaglia, G.
    MOVEMENT DISORDERS, 2020, 35 : S221 - S221
  • [38] Modulation of the basal ganglia by metabotropic glutamate receptors: Potential novel approaches for the treatment of Parkinson's disease
    Jones, CK
    Marino, MJ
    Nong, Y
    Valenti, O
    Kinney, GG
    Poisik, O
    Williams, L
    Smith, Y
    Conn, PJ
    NEUROPHARMACOLOGY, 2005, 49 : 251 - 251
  • [39] PET studies: in vivo monitoring of group I metabotropic glutamate receptors in Parkinson's disease rat
    Yamasaki, T.
    Fujinaga, M.
    Kawamura, K.
    Shimoda, Y.
    Furutsuka, K.
    Nengaki, N.
    Yui, J.
    Wakizaka, H.
    Hatori, A.
    Xie, L.
    Kumata, K.
    Zhang, M.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2014, 41 : S623 - S624
  • [40] The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer's Disease
    de Lima, Izabella B. Q.
    Ribeiro, Fabiola M.
    CURRENT NEUROPHARMACOLOGY, 2023, 21 (02) : 164 - 182
12345