The role of striatal metabotropic glutamate receptors in Parkinson's disease

被引：0
|
作者：
K. Ossowska
J. Konieczny
J. Wardas
K. Gołembiowska
S. Wolfarth
A. Pilc
机构：
[1]  Department of Neuro-Psychopharmacology,
[2] Institute of Pharmacology,undefined
[3] ,undefined
[4]  Department of Pharmacology,undefined
[5] Institute of Pharmacology,undefined
[6] and,undefined
[7]  Department of Neurobiology,undefined
[8] Institute of Pharmacology,undefined
[9] Polish Academy of Sciences,undefined
[10] Kraków,undefined
[11] Poland,undefined
来源：
Amino Acids | 2002年 / 23卷
关键词：
Keywords: Metabotropic glutamate receptors; Antiparkinsonian-like effects; Striatum;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 The primary cause of Parkinson's disease is a loss of dopamine in the corpus striatum. It has been postulated that this effect leads to disinhibition of the striopallidal pathway and secondarily, to a functional shift towards glutamatergic stimulation. The aim of the present study was to find out whether inhibition of glutamatergic transmission at a level of metabotropic glutamate receptors (mGluRs) in the striatum may alleviate parkinsonian-like symptoms in rats.
引用
收藏
页码：193 / 198
页数：5
相关论文
共 50 条
  • [1] The role of striatal metabotropic glutamate receptors in Parkinson's disease
    Ossowska, K
    Konieczny, J
    Wardas, J
    Golembiowska, K
    Wolfarth, S
    Pilc, A
    AMINO ACIDS, 2002, 23 (1-3) : 193 - 198
  • [2] Role of metabotropic glutamate receptors in striatal cholinergic transmission: Implications for Parkinson's disease
    Bonsi, P
    Cuomo, D
    Calabresi, P
    Bernardi, G
    MOVEMENT DISORDERS, 2004, 19 : S47 - S47
  • [3] Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease
    Bonsi, P.
    Cuomo, D.
    Picconi, B.
    Sciamanna, G.
    Tscherter, A.
    Tolu, M.
    Bernardi, G.
    Calabresi, P.
    Pisani, A.
    AMINO ACIDS, 2007, 32 (02) : 189 - 195
  • [4] Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson’s disease
    P. Bonsi
    D. Cuomo
    B. Picconi
    G. Sciamanna
    A. Tscherter
    M. Tolu
    G. Bernardi
    P. Calabresi
    A. Pisani
    Amino Acids, 2007, 32 : 189 - 195
  • [5] Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease
    不详
    AMINO ACIDS, 2005, 29 (01) : 22 - 23
  • [6] The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: Implications for the therapy of Parkinson's disease
    Wardas, J
    Pietraszek, M
    Wolfarth, S
    Ossowska, K
    NEUROSCIENCE, 2003, 122 (03) : 747 - 756
  • [7] The role of striatal glutamate receptors in models of Parkinson's disease
    Ossowska, K
    Lorenc-Koci, E
    Konieczny, J
    Wolfarth, S
    AMINO ACIDS, 1998, 14 (1-3) : 11 - 15
  • [8] The role of striatal glutamate receptors in models of Parkinson's disease
    K. Ossowska
    E. Lorenc-Koci
    J. Konieczny
    S. Wolfarth
    Amino Acids, 1998, 14 : 11 - 15
  • [9] Metabotropic glutamate receptors and Parkinson's disease
    Amalric, M.
    Lopez, S.
    NEUROPHARMACOLOGY, 2008, 55 (04) : 585 - 585
  • [10] Targeting striatal cholinergic interneurons in Parkinson's disease: Focus on metabotropic glutamate receptors
    Pisani, A
    Bonsi, P
    Centonze, D
    Gubellini, P
    Bernardi, G
    Calabresi, P
    NEUROPHARMACOLOGY, 2003, 45 (01) : 45 - 56
12345