The role of striatal metabotropic glutamate receptors in Parkinson's disease

被引：0
|
作者：
K. Ossowska
J. Konieczny
J. Wardas
K. Gołembiowska
S. Wolfarth
A. Pilc
机构：
[1]  Department of Neuro-Psychopharmacology,
[2] Institute of Pharmacology,undefined
[3] ,undefined
[4]  Department of Pharmacology,undefined
[5] Institute of Pharmacology,undefined
[6] and,undefined
[7]  Department of Neurobiology,undefined
[8] Institute of Pharmacology,undefined
[9] Polish Academy of Sciences,undefined
[10] Kraków,undefined
[11] Poland,undefined
来源：
Amino Acids | 2002年 / 23卷
关键词：
Keywords: Metabotropic glutamate receptors; Antiparkinsonian-like effects; Striatum;
D O I：
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学科分类号：
摘要：
 The primary cause of Parkinson's disease is a loss of dopamine in the corpus striatum. It has been postulated that this effect leads to disinhibition of the striopallidal pathway and secondarily, to a functional shift towards glutamatergic stimulation. The aim of the present study was to find out whether inhibition of glutamatergic transmission at a level of metabotropic glutamate receptors (mGluRs) in the striatum may alleviate parkinsonian-like symptoms in rats.
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页码：193 / 198
页数：5
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