Rapid modelling of cooperating genetic events in cancer through somatic genome editing

被引：0
|
作者：
Francisco J. Sánchez-Rivera
Thales Papagiannakopoulos
Rodrigo Romero
Tuomas Tammela
Matthew R. Bauer
Arjun Bhutkar
Nikhil S. Joshi
Lakshmipriya Subbaraj
Roderick T. Bronson
Wen Xue
Tyler Jacks
机构：
[1] David H. Koch Institute for Integrative Cancer Research,Department of Biology
[2] Massachusetts Institute of Technology,undefined
[3] Massachusetts Institute of Technology,undefined
[4] Tufts University,undefined
[5] Harvard Medical School,undefined
[6] Howard Hughes Medical Institute,undefined
[7] Massachusetts Institute of Technology,undefined
来源：
Nature | 2014年 / 516卷
关键词：
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中图分类号：
学科分类号：
摘要：
The CRISPR/Cas system has been used in mice for genome editing to introduce genetic alterations found in human lung tumours, and these genome modifications resulted in mouse lung tumours showing different histopathologies depending on the genes altered; the CRISPR/Cas system offers improved and faster ways to create animal models of human diseases such as cancer.
引用
收藏
页码：428 / 431
页数：3
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