Targeted therapy for small cell lung cancer

被引：0
|
作者：
Apar Kishor Ganti
Amit W. Panwalkar
机构：
[1] 987680 Nebraska Medical Center,Division of Oncology
[2] Omaha VA Medical Center,Hematology, Department of Internal Medicine
来源：
Targeted Oncology | 2007年 / 2卷
关键词：
Small cell lung cancer; Targeted therapy; Angiogenesis; Apoptosis; Vaccines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Small cell lung cancer (SCLC) is very aggressive clinically, and current cytotoxic therapy has only a limited impact on survival. The development of targeted therapy for SCLC has lagged behind that of non-small cell lung cancer. Current drugs under investigation include those targeting the angiogenetic, apoptotic, sonic hedgehog, and mammalian target of rapamycin (mTOR) pathways. Vaccines seem to be promising adjunctive therapies. This review will present the available data on these agents. Common genetic abnormalities seen in SCLC, which could serve as potential future targets are also discussed.
引用
收藏
页码：89 / 97
页数：8
相关论文
共 50 条
  • [31] Non-small cell lung cancer: the era of targeted therapy
    Antonoff, Mara B.
    D'Cunha, Jonathan
    LUNG CANCER-TARGETS AND THERAPY, 2012, 3 : 31 - 41
  • [32] Opportunities and obstacles of targeted therapy and immunotherapy in small cell lung cancer
    Yu, Lin
    Lai, Qinhuai
    Gou, Lantu
    Feng, Jiafu
    Yang, Jinliang
    JOURNAL OF DRUG TARGETING, 2021, 29 (01) : 1 - 11
  • [33] Targeted therapy in the treatment of non-small cell lung cancer
    Shepherd, Frances A.
    JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S13 - S14
  • [34] Non-small cell lung cancer: from targeted therapy to tailored therapy
    Malgieri, Simona
    Feliciano, Salvatore
    Bosso, Davide
    Federico, Piera
    Palmieri, Giovannella
    De Placido, Sabino
    Di Lorenzo, Giuseppe
    Buonerba, Carlo
    EXPERT OPINION ON PHARMACOTHERAPY, 2012, 13 (13) : 1817 - 1819
  • [35] Pharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer
    Haghgoo, Seyyed Mortaza
    Allameh, Abdolamir
    Mortaz, Esmaeil
    Garssen, Johan
    Folkerts, Gert
    Barnes, Peter J.
    Adcock, Ian M.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 754 : 88 - 97
  • [36] Mastering the Complex Targeted Therapy for Non-small Cell Lung Cancer
    Devarakonda, Siddhartha
    Govindan, Ramaswamy
    Morgensztern, Daniel
    CANCER CELL, 2020, 38 (03) : 320 - 322
  • [37] Molecular targeted therapy of patients with non-small-cell lung cancer
    Stencel, Katarzyna
    Swiniuch, Daria
    Ramlau, Rodryg
    ONCOLOGY IN CLINICAL PRACTICE, 2019, 15 (06): : 289 - 296
  • [38] Recent advances in targeted therapy for non-small cell lung cancer
    Ramalingam, Suresh
    Belani, Chandra P.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (02) : 245 - 257
  • [39] Targeted Therapy and Immunotherapy in the Treatment of Non-Small Cell Lung Cancer
    Shroff, Girish S.
    de Groot, Patricia M.
    Papadimitrakopoulou, Vassiliki A.
    Truong, Mylene T.
    Carter, Brett W.
    RADIOLOGIC CLINICS OF NORTH AMERICA, 2018, 56 (03) : 485 - +
  • [40] Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer
    Schulze, Arik Bernard
    Evers, Georg
    Kerkhoff, Andrea
    Mohr, Michael
    Schliemann, Christoph
    Berdel, Wolfgang E.
    Schmidt, Lars Henning
    CANCERS, 2019, 11 (05)
12345