Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

被引：0

作者：

Raffaella Di Micco

Gabriele Sulli

Miryana Dobreva

Michalis Liontos

Oronza A. Botrugno

Gaetano Gargiulo

Roberto dal Zuffo

Valentina Matti

Giovanni d'Ario

Erica Montani

Ciro Mercurio

William C. Hahn

Vassilis Gorgoulis

Saverio Minucci

Fabrizio d'Adda di Fagagna

机构：

[1] IFOM Foundation - FIRC Institute of Molecular Oncology Foundation,Department of Histology and Embryology

[2] Molecular Carcinogenesis Group,Department of Experimental Oncology

[3] School of Medicine,Department of Biomolecular Sciences and Biotechnologies

[4] University of Athens,undefined

[5] European Institute of Oncology,undefined

[6] DAC-Genextra Group,undefined

[7] Consortium for Genomic Technologies c/o IFOM-IEO Campus for Oncogenomics,undefined

[8] Dana-Farber Cancer Institute,undefined

[9] University of Milan,undefined

[10] Present address: NYU School of Medicine,undefined

[11] Department of Pathology,undefined

[12] 550 First Avenue,undefined

[13] New York,undefined

[14] NY 10016,undefined

[15] USA.,undefined

[16] Present address: The Netherlands Cancer Institute (NKI),undefined

[17] Division Molecular Genetics,undefined

[18] Plesmanlaan 121,undefined

[19] 1066 CX Amsterdam,undefined

[20] The Netherlands.,undefined

来源：

Nature Cell Biology | 2011年 / 13卷

关键词：

D O I：

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学科分类号：

摘要：

Different mechanisms have been implicated in the induction of senescence. Two of these mechanisms, the DNA damage response, which induces a replicative checkpoint, and the formation of heterochromatic foci, which leads to transcriptional repression, are found to act together in oncogene-expressing cells.

引用

页码：292 / 302

页数：10

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