Genome-wide association studies identify four ER negative–specific breast cancer risk loci

被引：0

作者：

Montserrat Garcia-Closas

Fergus J Couch

Sara Lindstrom

Kyriaki Michailidou

Marjanka K Schmidt

Mark N Brook

Nick Orr

Suhn Kyong Rhie

Elio Riboli

Heather S Feigelson

Loic Le Marchand

Julie E Buring

Diana Eccles

Penelope Miron

Peter A Fasching

Hiltrud Brauch

Jenny Chang-Claude

Jane Carpenter

Andrew K Godwin

Heli Nevanlinna

Graham G Giles

Angela Cox

John L Hopper

Manjeet K Bolla

Qin Wang

Joe Dennis

Ed Dicks

Will J Howat

Nils Schoof

Stig E Bojesen

Diether Lambrechts

Annegien Broeks

Irene L Andrulis

Pascal Guénel

Barbara Burwinkel

Elinor J Sawyer

Antoinette Hollestelle

Olivia Fletcher

Robert Winqvist

Hermann Brenner

Arto Mannermaa

Ute Hamann

Alfons Meindl

Annika Lindblom

Wei Zheng

Peter Devillee

Mark S Goldberg

Jan Lubinski

Vessela Kristensen

Anthony Swerdlow

机构：

[1] Institute of Cancer Research,Division of Genetics and Epidemiology

[2] Breakthrough Breast Cancer Research Centre,Department of Epidemiology

[3] The Institute of Cancer Research,Department of Public Health and Primary Care

[4] Mayo Clinic College of Medicine,Department of Preventive Medicine

[5] Mayo Clinic,Division of Preventive Medicine

[6] Harvard School of Public Health,Department of Cancer Biology

[7] Centre for Cancer Genetic Epidemiology,Department of Gynecology and Obstetrics

[8] University of Cambridge,Division of Cancer Epidemiology

[9] Netherlands Cancer Institute,Department of Pathology and Laboratory Medicine

[10] Antoni van Leeuwenhoek Hospital,Department of Obstetrics and Gynecology

[11] Keck School of Medicine,Department of Oncology

[12] Norris Comprehensive Cancer Center,Department of Medical Epidemiology and Biostatistics

[13] University of Southern California,Department of Clinical Biochemistry

[14] School of Public Health,Department of Oncology

[15] Imperial College,Department of Molecular Genetics

[16] Kaiser Permanente,Department of Obstetrics and Gynecology

[17] Institute for Health Research,Division of Cancer Studies

[18] Epidemiology Program,Department of Medical Oncology

[19] Cancer Research Center,Department of Clinical Genetics

[20] University of Hawaii,Division of Clinical Epidemiology and Aging Research

[21] Brigham and Women's Hospital,Department of Clinical Pathology

[22] Faculty of Medicine,Division for Gynaecological Tumor Genetics

[23] University of Southampton,Division of Gynaecology and Obstetrics

[24] Dana-Farber Cancer Institute,Department of Molecular Medicine and Surgery

[25] University Breast Center Franconia,Department of Medicine, Division of Epidemiology

[26] University Hospital Erlangen,Department of Human Genetics

[27] Jonsson Comprehensive Cancer Center,Department of Pathology

[28] David Geffen School of Medicine,Department of Medicine

[29] University of California,Division of Clinical Epidemiology

[30] Los Angeles,Department of Genetics and Pathology

[31] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology,Department of Genetics

[32] University of Tübingen,Faculty of Medicine (Faculty Division Ahus)

[33] German Cancer Research Center (DKFZ),Department of Epidemiology

[34] Australian Breast Cancer Tissue Bank,Department of Obstetrics and Gynaecology

[35] University of Sydney at the Westmead Millennium Institute,Division of Epidemiology and Prevention

[36] University of Kansas Medical Center,Department of Preventive and Predictive Medicine

[37] University of Helsinki and Helsinki University Central Hospital,Department of Surgery

[38] Cancer Epidemiology Centre,Department of Pathology

[39] The Cancer Council Victoria,Non

[40] School of Population Health,communicable Disease Epidemiology Department

[41] The University of Melbourne,Department of Surgery

[42] Cancer Research UK/Yorkshire Cancer Research Sheffield Cancer Research Centre,Department of Medical Oncology

[43] University of Sheffield,Department of Breast Surgery

[44] Centre for Molecular,Department of Internal Medicine

[45] Environmental,Department of Clinical Genetics

[46] Genetic and Analytic Epidemiology,Department of Oncology

[47] The University of Melbourne,Department of Breast Oncology

[48] Cancer Research UK,Department of Pathology and Molecular Diagnostics

[49] Cambridge Research Institute,Department of Oncology

[50] Li Ka Shing Centre,Pathology

来源：

Nature Genetics | 2013年 / 45卷

关键词：

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中图分类号：

学科分类号：

摘要：

Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35,194 controls, with replication using the iCOGS custom genotyping array in 40 studies, including 6,514 cases and 41,455 controls. They identify four loci associated with ER-negative but not ER-positive breast cancer.

引用

页码：392 / 398

页数：6

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