Regioselective C-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones

被引：0

作者：

M. M. Krayushkin

V. Z. Shirinian

D. M. Nikalin

A. A. Shimkin

机构：

[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

来源：

Russian Chemical Bulletin | 2004年 / 53卷

关键词：

alkylation; hydroxythiophene; α-halo ketones;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Regioselective C- or O-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones is possible, depending on the solvent nature. A convenient preparative method of C-alkylation was proposed and previously not easily accessible β-hydroxythiophene derivatives were synthesized.

引用

页码：631 / 634

页数：3

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