Regioselective C-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones

被引：0
|
作者：
M. M. Krayushkin
V. Z. Shirinian
D. M. Nikalin
A. A. Shimkin
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2004年 / 53卷
关键词：
alkylation; hydroxythiophene; α-halo ketones;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Regioselective C- or O-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones is possible, depending on the solvent nature. A convenient preparative method of C-alkylation was proposed and previously not easily accessible β-hydroxythiophene derivatives were synthesized.
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页码：631 / 634
页数：3
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