4-Hydroxy-2-Quinolones. 233*. Synthesis and Diuretic Activity of 9-Bromo-7-Hydroxy-5-Oxo-2,3-Dihydro-1H,5H-Pyrido[3,2,1-ij]Quinoline-6-Carboxylic Acid Anilides

被引：0
|
作者：
I. V. Ukrainets
N. Yu. Golik
I. N. Chernenok
机构：
[1] National University of Pharmacy,
来源：
Chemistry of Heterocyclic Compounds | 2013年 / 49卷
关键词：
4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; pyrido[3,2,1-; ]quinolines; bromination; diuretic activity;
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学科分类号：
摘要：
The ethyl ester of 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid reaction with bromine in anhydrous acetic acid producing a mixture of the 9-bromo-substituted product and 6-ethoxycarbonyl-5,7-dihydroxy-2,3-dihydro-1H-pyrido[3,2,1-ij]quinolinium tribromide in a 1:1 ratio. It has been established experimentally that the diuretic activity of 9-bromo-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxanilides increases substantially in comparison with their non-brominated analogs.
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页码：1323 / 1330
页数：7
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