The Sinonasal Tract: Another Potential "Hot Spot" for Carcinomas with Transcriptionally-Active Human Papillomavirus

被引：56

作者：

Lewis Jr. J.S. ^{[1
]}

Westra W.H. ^{[2
]}

Thompson L.D.R. ^{[3
]}

Barnes L. ^{[4
]}

Cardesa A. ^{[5
]}

Hunt J.L. ^{[6
]}

Williams M.D. ^{[7
]}

Slootweg P.J. ^{[8
]}

Triantafyllou A. ^{[9
]}

Woolgar J.A. ^{[9
]}

Devaney K.O. ^{[10
]}

Rinaldo A. ^{[11
]}

Ferlito A. ^{[11
]}

机构：

[1] Departments of Pathology and Immunology and Otolaryngology Head and Neck Surgery, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, St. Louis, MO

[2] Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD

[3] Department of Pathology, Woodland Hills Medical Center, Woodland Hills, CA

[4] Department of Pathology and Laboratory Medicine, University of Pittsburgh, Pittsburgh, PA

[5] Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona

[6] Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR

[7] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX

[8] Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen

[9] Oral Pathology, School of Dental Sciences and Dental Hospital, University of Liverpool, Liverpool

[10] Department of Pathology, Allegiance Health, Jackson, MI

[11] ENT Clinic, University of Udine, Udine

来源：

Head and Neck Pathology | 2014年 / 8卷 / 3期

关键词：

Human papillomavirus; Nonkeratinizing; p16; Sinonasal; Squamous cell carcinoma;

D O I：

10.1007/s12105-013-0514-4

中图分类号：

学科分类号：

摘要：

While high risk human papillomavirus (HPV) is well established as causative and clinically important for squamous cell carcinoma (SCC) of the oropharynx, its role in non-oropharyngeal head and neck SCC is much less clearly elucidated. In the sinonasal region, in particular, although it is a relatively uncommon site for SCC, as many as 20 % of SCC harbor transcriptionally-active high risk HPV. These tumors almost always have a nonkeratinizing morphology and may have a better prognosis. In addition, specific variants of SCC as well as other rare carcinoma types, when arising in the sinonasal tract, can harbor transcriptionally-active HPV. This article reviews the current literature on HPV in sinonasal carcinomas, attempts to more clearly demonstrate what tumors have it and how this relates to possible precursor lesions like inverted papilloma, and discusses the possible clinical ramifications of the presence of the virus. © 2013 Springer Science+Business Media New York.

引用

页码：241 / 249

页数：8

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