Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

被引：0

作者：

M. Niemi

J. T. Backman

M. Neuvonen

P. J. Neuvonen

机构：

[1] Helsinki University Central Hospital,Department of Clinical Pharmacology

来源：

Diabetologia | 2003年 / 46卷

关键词：

CYP2C8; CYP3A4; drug interaction; gemfibrozil; hypoglycaemia; itraconazole; repaglinide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：347 / 351

页数：4

共 30 条

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[22] The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose:: Evidence for mechanism-based inhibition of CYP2C8 in vivo
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[25] Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine
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[26] EFFECTS OF ITRACONAZOLE AND GEMFIBROZIL ON ARN-509 PHARMACOKINETICS (PK): COMPARISON OF IN SILICO PREDICTIONS BY PHYSIOLOGIC-BASED PK (PBPK) MODELING AND IN VIVO RESULTS.
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[27] Single-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites Alone and in Combination with Gemfibrozil, Itraconazole, or Rifampin in Healthy Subjects: A Randomized, Parallel-Group, Open-Label Study
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[29] Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole
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