Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

被引：0
|
作者：
C Lemos
G Jansen
G J Peters
机构：
[1] VU University Medical Center,Department of Medical Oncology
[2] Faculty of Medicine,Department of Biochemistry (U38
[3] University of Porto,FCT)
[4] VU University Medical Center,Department of Rheumatology
来源：
British Journal of Cancer | 2008年 / 98卷
关键词：
BCRP; multidrug resistance; polymorphisms; stem cells; targeted therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors.
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页码：857 / 862
页数：5
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