The Brain-Gut-Microbiome Axis: What Role Does it Play in Autism Spectrum Disorder?

被引：1
|
作者：
Luna R.A. [1 ,2 ]
Savidge T.C. [1 ,2 ]
Williams K.C. [3 ]
机构：
[1] Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX
[2] Texas Children’s Microbiome Center, Department of Pathology, Texas Children’s Hospital, Houston, TX
[3] Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH
来源：
Current Developmental Disorders Reports | 2016年 / 3卷 / 1期
基金：
美国国家卫生研究院;
关键词：
ASD; ASD behaviors; Autism spectrum disorders; Brain-gut axis; Central nervous system; Developmental disorders; Functional GI disorders; GI disorders; Gut microbiome; Review;
D O I：
10.1007/s40474-016-0077-7
中图分类号：
学科分类号：
摘要：
The brain-gut-microbiome axis refers to the interactions between the central nervous system, gastrointestinal (GI) system, and microorganisms that live in the gastrointestinal tract. Exploring these interactions provides a rationale for why gastrointestinal disorders commonly occur in children with autism spectrum disorders (ASD). Signs of altered brain-gut interactions that are closely associated with functional GI disorders (FGIDs) commonly occur in children with ASD. Studies of microbiome in ASD suggest that changes in the gut microbiome may be associated with ASD and with GI disorders in children with ASD. Further studies into the brain-gut-microbiome axis could lead to new techniques for identifying GI disorders in children with ASD and novel therapies for treating ASD behaviors. © 2016, Springer International Publishing Switzerland.
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收藏
页码：75 / 81
页数：6
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