Aging and DNA methylation

被引：0
|
作者：
Marc Jung
Gerd P Pfeifer
机构：
[1] Beckman Research Institute,
[2] Van Andel Research Institute,undefined
来源：
BMC Biology | / 13卷
关键词：
Global Hypomethylation; Polycomb Group Protein; Polycomb Complex; Epigenetic Clock; Polycomb Target Gene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.
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