Reconfiguration of DNA methylation in aging

被引:175
|
作者
Zampieri, Michele [1 ,2 ]
Ciccarone, Fabio [1 ,2 ]
Calabrese, Roberta [1 ,2 ]
Franceschi, Claudio [3 ]
Buerkle, Alexander [4 ]
Caiafa, Paola [1 ,2 ]
机构
[1] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, I-00161 Rome, Italy
[2] Pasteur Inst Fdn Cenci Bolognetti, I-00161 Rome, Italy
[3] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[4] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany
关键词
DNA methylation; Aging; Epigenetic reprogramming; 5-Methylcytosine; 5-Hydroxymethylcytosine; DE-NOVO METHYLATION; GENOME-WIDE METHYLATION; TUMOR-SUPPRESSOR GENES; CPG ISLAND METHYLATION; EMBRYONIC STEM-CELLS; PROMOTER METHYLATION; TET PROTEINS; NUCLEAR LAMINA; DEPENDENT ALTERATIONS; UNMETHYLATED STATE;
D O I
10.1016/j.mad.2015.02.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance-of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:60 / 70
页数:11
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