Phase II trial to topotecan in hepatocellular carcinoma: A Southwest Oncology Group study

被引：0

作者：

James G. Wall

Jacqueline K. Benedetti

Mark A. O'Rourke

Ronald B. Natale

John S. Macdonald

机构：

[1] Cabarrus Memorial Hospital,

[2] Southwest Oncology Group Statistical Center,undefined

[3] Ohio State University Health Center,undefined

[4] University of Southern California School of Medicine,undefined

[5] Temple University,undefined

来源：

Investigational New Drugs | 1997年 / 15卷

关键词：

hepatocellular carcinoma; topotecan; phase II trial;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Hepatocellular carcinoma remains a highly chemoresistant neoplasm. In this study of the topoisomerase I inhibitor topotecan a response rate of 13.9% (95% confidence interval 4.7%–29.5%) was obtained utilizing a five consecutive day bolus infusion schedule. There were no complete responses and the median survival was only eight months. Furthermore, treatment with topotecan produced significant toxicity with two-thirds of patients experiencing life-threatening (grade 4) neutropenia. When used in this dose and schedule, topotecan does not appear to be effective for patients with advanced hepatocellular carcinoma.

引用

页码：257 / 260

页数：3

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