The evolutionary history of lethal metastatic prostate cancer

被引：0
|
作者：
Gunes Gundem
Peter Van Loo
Barbara Kremeyer
Ludmil B. Alexandrov
Jose M. C. Tubio
Elli Papaemmanuil
Daniel S. Brewer
Heini M. L. Kallio
Gunilla Högnäs
Matti Annala
Kati Kivinummi
Victoria Goody
Calli Latimer
Sarah O'Meara
Kevin J. Dawson
William Isaacs
Michael R. Emmert-Buck
Matti Nykter
Christopher Foster
Zsofia Kote-Jarai
Douglas Easton
Hayley C. Whitaker
David E. Neal
Colin S. Cooper
Rosalind A. Eeles
Tapio Visakorpi
Peter J. Campbell
Ultan McDermott
David C. Wedge
G. Steven Bova
机构：
[1] Cancer Genome Project,Department of Human Genetics
[2] Wellcome Trust Sanger Institute,Norwich Medical School and Department of Biological Sciences
[3] KU Leuven,Division of Genetics and Epidemiology
[4] Cancer Research UK London Research Institute,Department of Oncology
[5] University of East Anglia,Department of Surgical Oncology
[6] The Genome Analysis Centre,undefined
[7] Institute of Biosciences and Medical Technology,undefined
[8] BioMediTech,undefined
[9] University of Tampere and Fimlab Laboratories,undefined
[10] Tampere University Hospital,undefined
[11] The James Buchanan Brady Urological Institute,undefined
[12] Johns Hopkins School of Medicine,undefined
[13] Laboratory of Pathology,undefined
[14] National Cancer Institute,undefined
[15] National Institutes of Health,undefined
[16] University of Liverpool and HCA Pathology Laboratories,undefined
[17] The Institute Of Cancer Research,undefined
[18] Centre for Cancer Genetic Epidemiology,undefined
[19] University of Cambridge,undefined
[20] Uro-oncology Research Group,undefined
[21] Cancer Research UK Cambridge Institute,undefined
[22] University of Cambridge,undefined
[23] Addenbrooke's Hospital,undefined
[24] Royal Marsden NHS Foundation Trust,undefined
[25] and ,undefined
[26] ,undefined
[27] † Present address: Avoneaux Medical Institute,undefined
[28] Oxford,undefined
[29] Maryland 21654,undefined
[30] USA.,undefined
来源：
Nature | 2015年 / 520卷
关键词：
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中图分类号：
学科分类号：
摘要：
The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers; an important observation was that metastases could be re-seeded multiple times, and spread from one tumour to another was frequently seen.
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页码：353 / 357
页数：4
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