BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery

被引：0
|
作者：
Roman Kombarov
Andrea Altieri
Dmitry Genis
Mikhail Kirpichenok
Valeriy Kochubey
Natalia Rakitina
Zoya Titarenko
机构：
[1] ASINEX Ltd,
来源：
Molecular Diversity | 2010年 / 14卷
关键词：
Scaffold design; Compound libraries; Natural products; Diversity;
D O I：
暂无
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学科分类号：
摘要：
The analysis of known drugs (Comprehensive Medicinal Chemistry database (2008 version): http://www.mdl.com/products/knowledge/medicinal_chem/index.jsp) and natural products (Koch et al., Proc Natl Acad Sci USA 102:17272–17277, 2008) has led to the identification of privileged saturated and aromatic heterocyclic ring pairs that we have termed as “BioCores.” This article explains how the BioCores can be used for the design of novel lead-like scaffolds.
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页码：193 / 200
页数：7
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