Preparation of Gallic Acid – Anhydride Conjugate and Evaluation of Prodrug Release Through Pva-Based Hydrogel

被引：0
|
作者：
Rahul R. Mahire
Deepika S. Agrawal
Devanand K. Patil
Dhananjay H. More
机构：
[1] North Maharashtra University,School of Chemical Science
[2] North Maharashtra University,University Institute of Chemical Technology
来源：
Pharmaceutical Chemistry Journal | 2018年 / 52卷
关键词：
gallic acid – anhydride conjugate; prodrug; poly(vinyl alcohol) (PVA); hydrogel; prodrug release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In continuation of our previous work, we have studied controlled release of gallic acid – anhydride (GAAN) conjugate prodrug through crosslinked-PVAbased hydrogel. The GAAN conjugate prodrug was prepared and incorporated into PVA-based hydrogel in order to formulate a drug delivery system with controlled release properties. The loaded and unloaded hydrogels were investigated by FTIR spectroscopy. Their thermal stability was studied by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The drug release was studied spectrophotometrically, and the obtained data were interpreted in the framework of zero-order, first-order, Higuchi and Korsmeyer – Peppas models.
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页码：139 / 144
页数：5
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