Copines: a ubiquitous family of Ca2+-dependent phospholipid-binding proteins

被引:0
|
作者
J. L. Tomsig
C. E. Creutz
机构
[1] Department of Pharmacology,
[2] University of Virginia,undefined
[3] 1300 Jefferson Park Ave. Charlottesville,undefined
[4] Virginia 22908 (USA),undefined
[5] Fax + 1 434 982 3878,undefined
[6] e-mail: creutz@virginia.edu,undefined
关键词
Key words. Copines; calcium; C2 domain; phospholipids; Arabidopsis; integrin A domain.;
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摘要
The copines are a novel family of ubiquitous Ca2+-dependent, phospholipid-binding proteins. They contain two Ca2+- and phospholipid-binding domains known as 'C2 domains' present in proteins such as protein kinase C, phospholipase C and synaptotagmin. Copines are thought to be involved in membrane-trafficking phenomena because of their phospholipid-binding properties. They may also be involved in protein-protein interactions since they contain a domain similar to the protein-binding 'A domain' of integrins. The biochemistry, gene structure, tissue distribution and possible biological roles of copines are discussed, including recent observations with Arabidopsis that indicate that copines may be involved in cell division and growth.
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页码:1467 / 1477
页数:10
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