Carnitine Palmitoyltransferase-I and Regulation of Mitochondrial Fatty Acid Oxidation

被引：0
|
作者：
Janos Kerner
Charles L. Hoppel
机构：
[1] Case Western Reserve University,Department of Nutrition
[2] Case Western Reserve University,Department of Medicine and Pharmacology
[3] Medical Research Service,Louis Stokes Department of Veterans Affairs Medical Center
来源：
Monatshefte für Chemie / Chemical Monthly | 2005年 / 136卷
关键词：
Keywords. Carnitine palmitoyltransferase; Malonyl-CoA; Fatty acids; Lipids; Phosphorylations.;
D O I：
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学科分类号：
摘要：
Carnitine palmitoyltransferase-I catalyzes the regulated step in overall mitochondrial fatty acid oxidation. The enzyme is controlled by the steady state level of malonyl-CoA and the enzyme’s sensitivity to inhibition by malonyl-CoA. The former is established by the activities of acetyl-CoA carboxylase 2 and malonyl-CoA decarboxylase, while the latter is influenced by post-translational modification (phosphorylation) of CPT-I and/or by changes in the lipid environment of CPT-I.
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页码：1311 / 1323
页数：12
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