Carnitine Palmitoyltransferase-I and Regulation of Mitochondrial Fatty Acid Oxidation

被引：0

作者：

Janos Kerner

Charles L. Hoppel

机构：

[1] Case Western Reserve University,Department of Nutrition

[2] Case Western Reserve University,Department of Medicine and Pharmacology

[3] Medical Research Service,Louis Stokes Department of Veterans Affairs Medical Center

来源：

Monatshefte für Chemie / Chemical Monthly | 2005年 / 136卷

关键词：

Keywords. Carnitine palmitoyltransferase; Malonyl-CoA; Fatty acids; Lipids; Phosphorylations.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Carnitine palmitoyltransferase-I catalyzes the regulated step in overall mitochondrial fatty acid oxidation. The enzyme is controlled by the steady state level of malonyl-CoA and the enzyme’s sensitivity to inhibition by malonyl-CoA. The former is established by the activities of acetyl-CoA carboxylase 2 and malonyl-CoA decarboxylase, while the latter is influenced by post-translational modification (phosphorylation) of CPT-I and/or by changes in the lipid environment of CPT-I.

引用

页码：1311 / 1323

页数：12

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