Evaluation of two commercially available rapid diagnostic tests for Lyme borreliosis

被引：0
|
作者：
P. W. Smit
S. Kurkela
M. Kuusi
O. Vapalahti
机构：
[1] European Centre for Disease Prevention and Control,European Program for Public Health Microbiology Training
[2] National Institute for Health and Welfare,Department of Infectious Disease Surveillance and Control
[3] University of Helsinki,Faculty of Medicine
[4] Helsinki University Central Hospital Laboratory,Faculty of Veterinary Medicine
[5] University of Helsinki,undefined
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2015年 / 34卷
关键词：
Lyme Disease; Rapid Diagnostic Test; Borrelia Burgdorferi; Lyme Borreliosis; TPPA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The diagnosis of Lyme disease is very complicated and a single diagnostic method cannot exclude infection. We assessed the performance of two commercially available Borrelia burgdorferi rapid diagnostic tests (RDT) in comparison to multiple laboratory-based diagnostic assays using specimens with a gradually increasing probability of Borrelia infection. Based on 200 specimens, the analytical sensitivities for IgG and IgM were 18 and 23 % for the Lyme RDT and 24 and 32 % for the Borreliose Complete RDT. The sensitivity for detecting diagnosed Lyme borreliosis cases was low (26 % Lyme RDT and 32 % with the Borreliose Complete RDT respectively), whereas the specificity was good (85 % Lyme RDT and 88 % Borreliose Complete). Based on this evaluation, the performance of RDTs in detecting Lyme borreliosis appeared to be below that of laboratory-based diagnostics.
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页码：109 / 113
页数：4
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