Hypoxia-Inducible Factors and Cancer

被引：162
|
作者：
Jun J.C. [1 ]
Rathore A. [1 ]
Younas H. [1 ]
Gilkes D. [2 ]
Polotsky V.Y. [1 ]
机构：
[1] Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Rm 5A50.B, Baltimore, 21224, MD
[2] Division of Breast Cancer, Department of Oncology, Johns Hopkins University, Baltimore, MD
来源：
Current Sleep Medicine Reports | 2017年 / 3卷 / 1期
基金：
美国国家卫生研究院;
关键词：
Cancer; HIF; Hypoxia; Metabolism; Sleep apnea; VEGF;
D O I：
10.1007/s40675-017-0062-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: Hypoxia-inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell differentiation. In addition, we examine the proposed relationship between respiratory-related hypoxia, HIFs, and cancer. Recent Findings: HIFs are increased in many forms of cancer and portend a poor prognosis and response to therapy. Summary: HIFs play a critical role in various stages of carcinogenesis. HIF and its transcription targets may be useful as biomarkers of disease and therapeutic targets for cancer. © 2017, Springer International Publishing AG.
引用
收藏
页码：1 / 10
页数：9
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