Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

被引：0

作者：

Ly P Vu

Camila Prieto

Elianna M Amin

Sagar Chhangawala

Andrei Krivtsov

M Nieves Calvo-Vidal

Timothy Chou

Arthur Chow

Gerard Minuesa

Sun Mi Park

Trevor S Barlowe

James Taggart

Patrick Tivnan

Raquel P Deering

Lisa P Chu

Jeong-Ah Kwon

Cem Meydan

Javier Perales-Paton

Arora Arshi

Mithat Gönen

Christopher Famulare

Minal Patel

Elisabeth Paietta

Martin S Tallman

Yuheng Lu

Jacob Glass

Francine E Garret-Bakelman

Ari Melnick

Ross Levine

Fatima Al-Shahrour

Marcus Järås

Nir Hacohen

Alexia Hwang

Ralph Garippa

Christopher J Lengner

Scott A Armstrong

Leandro Cerchietti

Glenn S Cowley

David Root

John Doench

Christina Leslie

Benjamin L Ebert

Michael G Kharas

机构：

[1] Molecular Pharmacology Program,Department of Pediatric Oncology

[2] Center for Cell Engineering,Department of Medicine, Division of Hematology/Oncology

[3] Center for Stem Cell Biology,Division of Hematology

[4] and Center for Experimental Therapeutics,Department of Physiology and Biophysics

[5] Memorial Sloan Kettering Cancer Center,Department of Epidemiology and Biostatistics

[6] Physiology,Department of Medicine

[7] Biophysics and Systems Biology Graduate Program,Department of Medicine

[8] Weill Cornell Graduate School of Medical Sciences,Department of Medicine

[9] Cornell University,Department of Medicine and Department of Biochemistry and Molecular Genetics

[10] Computational Biology Program,Division of Hematology and Medical Oncology, Departments of Medicine and Pharmacology

[11] Memorial Sloan Kettering Cancer Center,Department of Clinical Genetics

[12] Cancer Biology and Genetics Program,Department of Animal Biology, Department of Cell and Developmental Biology

[13] Memorial Sloan Kettering Cancer Center,undefined

[14] Dana-Farber Cancer Institute,undefined

[15] Harvard Medical School,undefined

[16] Weill Cornell Medical College,undefined

[17] Harvard Medical School,undefined

[18] Brigham and Woman's Hospital,undefined

[19] Whitehead Institute,undefined

[20] Institute for Computational Biomedicine,undefined

[21] Weill Cornell Medical College,undefined

[22] Translational Bioinformatics Unit,undefined

[23] Clinical Research Programme,undefined

[24] Spanish National Cancer Research Centre,undefined

[25] Memorial Sloan Kettering Cancer Center,undefined

[26] Human Oncology and Pathogenesis Program,undefined

[27] Leukemia Service,undefined

[28] Memorial Sloan Kettering Cancer Center,undefined

[29] Montefiore Medical Center,undefined

[30] Leukemia Service,undefined

[31] Memorial Sloan Kettering Hospital,undefined

[32] University of Virginia,undefined

[33] Weill Cornell Medical College,undefined

[34] Cornell University,undefined

[35] Lund University,undefined

[36] RNAi Core,undefined

[37] Memorial Sloan Kettering Cancer Center,undefined

[38] and Institute for Regenerative Medicine,undefined

[39] Schools of Veterinary Medicine and Medicine,undefined

[40] University of Pennsylvania,undefined

[41] Discovery Sciences,undefined

[42] Janssen Research and Development,undefined

[43] Broad Institute,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in a myeloid leukemia stem cell program.

引用

页码：866 / 875

页数：9

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