Kainate receptor pharmacology and physiology

被引:0
|
作者
D. Bleakman
机构
[1] Eli Lilly and Company,
[2] Lilly Research Laboratories,undefined
[3] Lilly Corporate Center,undefined
[4] Indianapolis (Indiana 46285-0510,undefined
[5] USA),undefined
[6] Fax +1 317 276 5545,undefined
[7] e-mail: bleakman_david@lilly.com,undefined
关键词
Key words. Glutamate receptors; antagonist; desensitization; agonist.;
D O I
暂无
中图分类号
学科分类号
摘要
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists. These compounds have allowed scientists to begin to probe the functional properties of these receptors in neurons and gain a better understanding of the role of these receptors in the nervous system.
引用
收藏
页码:558 / 566
页数:8
相关论文
共 50 条
  • [11] The calcium-sensing receptor: from physiology to pharmacology
    Ranieri, Marianna
    Schepelmann, Martin
    Valenti, Giovanna
    Kallay, Eniko
    Riccardi, Daniela
    FRONTIERS IN PHYSIOLOGY, 2023, 14
  • [12] Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric Disorders
    Gordon J. Lees
    Drugs, 2000, 59 : 33 - 78
  • [13] Molecular physiology of kainate receptors
    Lerma, J
    Paternain, AV
    Rodríguez-Moreno, A
    López-García, JC
    PHYSIOLOGICAL REVIEWS, 2001, 81 (03) : 971 - 998
  • [14] From Pharmacology to Physiology: Endocrine Functions of μ-Opioid Receptor Networks
    Jaschke, Nikolai
    Paehlig, Sophie
    Pan, Ying-Xian
    Hofbauer, Lorenz C.
    Goebel, Andy
    Rachner, Tilman D.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2021, 32 (05): : 306 - 319
  • [15] Genetic manipulation of mice for analysis of β-adrenergic receptor pharmacology and physiology
    Angelotti, T
    Desai, K
    Kobilka, B
    FASEB JOURNAL, 2003, 17 (04): : A210 - A210
  • [16] Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity
    Conti, P
    De Amici, M
    De Sarro, G
    Stensbol, TB
    Brauner-Osborne, H
    Madsen, U
    De Micheli, C
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (20) : 3759 - 3762
  • [17] BELGIAN PHYSIOLOGY AND PHARMACOLOGY ASSOCIATION AND NETHERLANDS PHYSIOLOGY AND PHARMACOLOGY ASSOCIATION
    不详
    ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE, 1974, 82 (02): : 313 - 313
  • [18] Physiology and pharmacology of glucagon-like peptide-1 receptor
    Kurkin, D. V.
    Bakulin, D. A.
    Morkovin, E. I.
    Petrov, V. I.
    Strygin, A. V.
    Koryanova, K. N.
    Gorbunova, Yu. V.
    Kolosov, Yu. A.
    Ivanova, O. V.
    Pavlova, E. V.
    Dzhavahyan, M. A.
    Zaborovsky, A. V.
    Saparova, V. B.
    Makarenko, I. E.
    Drai, R. I.
    Chumachenko, A. N.
    PHARMACY & PHARMACOLOGY-FARMATSIYA I FARMAKOLOGIYA, 2023, 11 (04): : 347 - 380
  • [19] Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
    Martel, Jean Claude
    McArthur, Silvia Gatti
    FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [20] Kainate receptors: Pharmacology, function and therapeutic potential
    Jane, David E.
    Lodge, David
    Collingridge, Graham L.
    NEUROPHARMACOLOGY, 2009, 56 (01) : 90 - 113